B Molecular provides molecular tools and services supporting research in molecular biology and drug discovery

Our products

Tools dedicated to capture of ubiquitylated proteins and LC3/GABARAP proteins.

UBI TRAPS

KIT UBI trap-A for Western-blot

This kit includes all reagents required to capture K48 linked polyubiquitin chains

KIT UBI trap-B for Western-blot

This kit includes all reagents required to capture K63 linked polyubiquitin chains

UBI trap-A (GST)

This affinity matrix captures K48 linked polyubiquitin chains

UBI trap-B (GST)

This affinity matrix captures K63 linked polyubiquitin chains

KIT LC3 trap-F for Western-blot

This kit includes all reagents required to capture GABARAP, GABARAP-L1 and GABARAP-L2 proteins

KIT LC3 trap-W for Western-blot

This kit includes all reagents required to capture LC3A and LC3B proteins

LC3 trap-F (GST)

This affinity matrix binds GABARAP, GABARAP-L1 and GABARAP-L2 proteins

LC3 trap-W (GST)

This affinity matrix binds LC3A and LC3B proteins

GST control

This GST protein is used as control to estimate the background in Western blot and MS analyses

Why choose us

More than 25 years of experience in molecular biology

Co-founders are well-known specialists of protein interaction and degradation (see references)

Result commitment

High quality products and services created by researchers for researchers

Advice and support prior and after purchasing

We support new and advanced users to optimize the use of our products

Trusted partner

B Molecular is a privileged partner of industrial and academic laboratories

Testimonials

" The use of TUBEs as components of in vitro and cell-based assays presents the unique feature of confirming and assessing the polyubiquitination of a POI in response to inhibitors, activators, or PROTAC® molecules. Therefore, TUBEs not only play a big role in studying the UPS but also have a huge potential for speeding up the drug discovery process. "

Kadimisetty K., Sheets K.J., Gross P.H., Zerr M.J., Ouazia D. (2021) Tandem Ubiquitin Binding Entities (TUBEs) as Tools to Explore Ubiquitin-Proteasome System and PROTAC Drug Discovery. In: Cacace A.M., Hickey C.M., Békés M. (eds) Targeted Protein Degradation. Methods in Molecular Biology, vol 2365. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1665-9_10

" TUBEs allow the identification and characterization of Ub chains, and novel substrates for deubiquitylases (DUBs) and Ub ligases (E3s). "

Mattern M, Sutherland J, Kadimisetty K, Barrio R, Rodriguez MS. (2019) Using Ubiquitin Binders to Decipher the Ubiquitin Code. Trends Biochem Sci. Jul;44(7):599-615. doi: 10.1016/j.tibs.2019.01.011. Epub 2019 Feb 25.

" LC3-traps are versatile tools that can be adapted to multiple applications to monitor selective autophagy events in distinct physiologic and pathologic circumstances. "

Quinet G, Génin P, Ozturk O, Belgareh-Touzé N, Courtot L, Legouis R, Weil R, Cohen MM, Rodriguez MS. (2022) Exploring selective autophagy events in multiple biologic models using LC3-interacting regions (LIR)-based molecular traps. Sci Rep. 2022 May 10;12(1):7652. doi: 10.1038/s41598-022-11417-z.

Our latest news

News

B Molecular moves to new laboratory facilities at Pierre Potier Center in Toulouse

A laboratory facility dedicated to research & production

avril 26, 2023

B Molecular is part of Bpifrance deeptech & Toulouse Tech Transfer program

About us

Founded in 2021 and headquartered in Toulouse, France. B Molecular develops, manufactures and distributes molecular tools for biotechnology research and drug discovery.

The company supports its client by offering both catalogue tools as well and tailor-made solutions.

B Molecular currently offers capture tools dedicated to ubiquitylated proteins and LC3/GABARAP proteins.

In parallel, B Molecular develops notably capture tools for NEDDylated proteins as well as SUMOylated proteins.

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